QUOTE (Blitz @ Feb 4 2008, 09:27 PM)

Uhm, pardon my ignorance of the "Paleo" diet, but my instinct tells me all that bacon and grease is a great way to get a coronary (i.e. heart attack). Am I missing something here?
Here's a bit of info from 3 institutes-all basically the same info. My lab lab as well as many others treat Mayo as sort of a gold standard for cardiac info....
From Mayo clinic:Causes
Atherosclerosis is a slow, progressive disease that may begin as early as childhood. Although the exact cause is unknown, researchers suspect that atherosclerosis starts with damage or injury to the inner layer of an artery. The damage may be caused by:
High blood pressure
High cholesterol
An irritant, such as nicotine
Certain diseases, such as diabetes
Once the inner wall of an artery is damaged, blood cells called platelets often clump at the injury site to try to repair the artery, leading to inflammation. Over time, fatty deposits (plaques) made of cholesterol and other cellular waste products also accumulate at the injury and harden, narrowing your arteries. The organs and tissues connected to the blocked arteries then don't receive enough blood to function properly.
Eventually pieces of the fatty deposits may rupture and enter your bloodstream. This can cause a blood clot to form and damage your organs, such as in a heart attack. A blood clot can also travel to other parts of your body and partially or totally block blood flow to another organ.
From NIH:What Causes Atherosclerosis?
The exact cause of atherosclerosis isn't known. However, studies show that atherosclerosis is a slow, complex disease that may start in childhood. It develops faster as you age.
Atherosclerosis may start when certain factors damage the inner layers of the arteries. These factors include:
Smoking
High amounts of certain fats and cholesterol in the blood
High blood pressure
High amounts of sugar in the blood due to insulin resistance or diabetes
When damage occurs, your body starts a healing process. Fatty tissues release compounds that promote this process. This healing causes plaque to build up where the arteries are damaged.
Over time, the plaque may crack. Blood cells called platelets (PLATE-lets) clump together to form blood clots where the cracks are. This narrows the arteries more and worsens angina (chest pain) or causes a heart attack.
Researchers continue to look at why atherosclerosis develops. They hope to find answers to such questions as:
Why and how do the arteries become damaged?
How does plaque develop and change over time?
Why does plaque break open and lead to clots?
From American Heart Association:How does atherosclerosis start?
Atherosclerosis is a slow, complex disease that typically starts in childhood and often progresses when people grow older. In some people it progresses rapidly, even in their third decade. Many scientists think it begins with damage to the innermost layer of the artery. This layer is called the endothelium (en"do-THE'le-um). Causes of damage to the arterial wall include:
elevated levels of cholesterol and triglyceride (tri-GLIS'er-id) in the blood
high blood pressure
tobacco smoke
diabetes
Tobacco smoke greatly worsens atherosclerosis and speeds its growth in the coronary arteries, the aorta and arteries in the legs. (The coronary arteries bring blood to the heart muscle; the aorta is the large vessel that the heart pumps blood through to the body.)
Because of the damage to the endothelium, fats, cholesterol, platelets, cellular waste products, calcium and other substances are deposited in the artery wall. These may stimulate artery wall cells to produce other substances that result in further buildup of cells.
These cells and surrounding material thicken the endothelium significantly. The artery's diameter shrinks and blood flow decreases, reducing the oxygen supply. Often a blood clot forms near this plaque and blocks the artery, stopping the blood flow.
What does research show?
Males and people with a family history of premature cardiovascular disease have an increased risk of atherosclerosis. These risk factors can't be controlled. Research shows the benefits of reducing the controllable risk factors for atherosclerosis:
High blood cholesterol (especially LDL or "bad" cholesterol over 100 mg/dL)
Cigarette smoking and exposure to tobacco smoke
High blood pressure
Diabetes mellitus
Obesity
Physical inactivity
Research also suggests that inflammation in the circulating blood may play an important role in triggering heart attacks and strokes. Inflammation is the body's response to injury, and blood clotting is often part of that response. Blood clots, as described above, can slow down or stop blood flow in the arteries.